CT Scans Reveal H7N9 Pneumonia Different from Other Strains

The study’s findings were published on July 2, 2013, online in the journal Radiology. “The severity of these findings is associated with the severity of the clinical condition of the patients,” said study coauthor Zhiyong Zhang, MD, PhD, from the department of radiology at Shanghai Public Health Clinical Center and Shanghai Medical College of Fudan University (China).

H7N9 is a recently discovered subtype of avian influenza virus, also known as “bird flu.” Cases of bird flu infection in humans typically result from direct or close contact with infected poultry, such as domesticated chickens, pigeons, or ducks, or surfaces contaminated with secretions and excretions from infected birds. The first human outbreak of H7N9 was reported in China in March 2013. This new strain in humans has caused severe and rapidly progressing respiratory illness. H7N9 can cause acute respiratory distress syndrome, organ failure, and death.

Dr. Zhang and colleagues, for the study, evaluated the clinical data and radiologic files of 12 patients with avian-origin influenza A H7N9 virus who were admitted to Shanghai Public Health Clinical Center between April 3, 2013, and April 20, 2013. The 12 patients included nine men and three women, 47 to 81 years old (mean age, 66 years).

None of the patients raised pigeons or lived in or near a pigeon-infested area. One patient kept chickens at home, and four patients had gone to various farmers’ markets before the symptom onset. All other patients had no clear history of exposure to poultry. All patients exhibited fever with temperature of 38–40 °C, cough, shortness of breath, and white phlegm and loss of strength at the onset of the disease or within one week. They quickly progressed to severe pneumonia and acute respiratory distress syndrome.

The intervals between the onset of symptoms and the first imaging examinations ranged from one to six days for chest X-rays and two to nine days for computed tomography (CT) imaging. Chest X-rays were taken every one or two days thereafter to monitor disease progression and treatment response. To assess disease progression and possible complications, 10 of the patients underwent follow-up computed tomography (CT) two to eight days after initial examination.

The imaging findings included ground-glass opacity (a hazy area in the lungs with the appearance of ground glass) in all 12 patients, consolidations (regions of lung tissue filled with liquid) in 11 patients, air bronchograms (air-filled bronchi that are visible by swelling in neighboring tissues) in 11 patients, and interlobular septal thickening (thickening of pulmonary connective tissue) in 11 patients. Lung lesions involved three or more lobes in all cases, but were mostly detected in right lower lobe. Follow-up CT imaging in 10 patients showed interval improvement of the lesions in three patients and worsening of the lesions in seven patients. Imaging findings closely mirrored the overall clinical severity of the disease.

“The distribution and very rapid progression of consolidations, ground-glass opacity, and air bronchograms, with interstitial changes, in H7N9 pneumonia help differentiate it from other causes of pneumonia,” Dr. Zhang said.

Whereas these imaging characteristics are comparable to those found in other respiratory diseases, such as H1N1, H5N1 and severe acute respiratory syndrome (SARS), there are differences. “Both H1N1 pneumonia and SARS distribute more peripherally, with more changes in the spaces between tissues, and progress less rapidly than H7N9,” Dr. Zhang said. “In our study, the right lower lung was most likely to be involved, while there’s no lobar predilection in findings of H5N1 influenza.”

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Shanghai Medical College of Fudan University