fMRI Offers Biofeedback Signals for the Brain

Andrea Caria and colleagues used this specialized imaging technique during training sessions in three groups of healthy participants who were asked to evaluate visual emotional stimuli (negative or neutral pictures). The scientists were interested in the signals generated by the insula, a brain region implicated in emotion regulation. While performing the test, the investigators provided the subjects with specific, unspecific, or no feedback about the extent of the activation of the insula.

The investigators discovered that the individuals who received specific feedback were able to increase the activity of the insula and perceived the negative pictures as being more unpleasant. The opposite was also true, i.e., when the insula's level of activity was decreased, a reduced sensitivity to negative stimuli was seen. The two other groups, who received unspecific or no feedback, were not able to enhance insula activity and showed no changes in subjective emotional responses.

The study was published in the September 1, 2010, issue of the journal Biological Psychiatry. The lead author, Dr. Andrea Caria, from the department of cognitive science, University of Trento (Italy), commented, "Our study demonstrates that voluntary control of emotionally important brain systems is possible. More importantly, after learning to voluntarily regulate the insula, the participants experienced emotionally negative material as more aversive than before training. This means that individuals can modify their perception to aversive stimuli.”

"This technique may provide a mechanism to obtain some measure of voluntary control over the activity of particular brain regions, and thus mental processes, that are typically beyond our reach. It may open new avenues for cognitive and behavioral therapies,” added Dr. John Krystal, Editor of Biological Psychiatry.

The authors, from institutions including the University of Trento, Max Planck Institute for Biological Cybernetics (Tübingen, Germany), and the Eberhard-Karls-University of Tubingen (Tübingen, Germany), agreed, noting that their findings may be applicable for the development of innovative approaches for the clinical treatment of emotional disorders such as antisocial behavior or social phobia that have shown hypoactivity and overactivity, respectively, in the insular region. However, more research is necessary before such treatments may become available.


Related Links:
University of Trento
Max Planck Institute for Biological Cybernetics
Eberhard-Karls-University of Tubingen