Biologic-Based Materials Aid Reconstructive Surgery

The bioscaffolds can support a variety of surgical techniques and procedures, with an emphasis on ventral hernia repair and abdominal wall reconstruction. Restella is available in a range of sizes--up to 25×40 cm (1,000 cm2)--thicknesses, and degrees of reinforcement, and can be trimmed to size.

The sterile polymer is embedded in a biologic extracellular matrix (ECM) derived from ovine (sheep) rumen, which has been optimized in order to reduce foreign body response, minimize inflammation, and enable functional tissue remodeling through hundreds of pores that allow fluid transfer through the scaffold, with no evidence remaining of interlayer seroma after a short period of just four weeks. The interwoven polymer also helps provide tissue support, along with improved handling and load-sharing capability.

“Our success in applying the advantages of our technology platform to develop Restella reconstructive bioscaffolds is another example of TELA Bio's unique ability to bring innovation and cost savings to address a wide range of needs in surgery,” said Antony Koblish, president and CEO of TELA Bio. “These products were purposefully engineered to allow for rapid tissue integration and revascularization and biomechanical control.”

Ruminant animals such as sheep, cattle, goats, deer, and llamas have a four-chambered stomach, which include the reticulum, rumen, omasum, and abomasum. Structures in each chamber are unique, with the reticulum sporting a honeycomb pattern, the rumen characterized with thousands of papillae that increase surface area, and the omasum and abomasum with numerous folds of tissue. The rumen itself serves as a large fermentation vat in which microorganisms break down feed the animal cannot. As part of this process, they produce by-products, such as volatile fatty acids (VFAs), which the animal absorbs and uses as energy.

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