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Synthetic Surgical Sealant Prevents Blood Leakage

By HospiMedica staff writers
Posted on 31 May 2001
In a clinical study involving 264 treated sites and 148 patients, sealing with a new synthetic self-polymerizing gel was immediate in 47% of treated sites, compared to 20% with the control, a hemostatic agent. More...
The gel is to be used for sealing around vascular reconstructions and vascular incision lines to prevent the leakage of blood.

Called CoSeal, the gel consists of two synthetic liquids that self-polymerize in seconds at the site of application to form a flexible hydrogel seal. CoSeal does not require a primer coat or extra equipment such as light sources or heat to be activated. The gel is designed for us in minimally invasive surgeries as well as in standard open surgical procedures. Since it is a mechanical barrier to leakage, CoSeal can work in patients with normal or compromised coagulation. Developed by Cohesion Technologies, Inc. (Palo Alto, CA, USA), CoSeal has received the CE Mark from the European Union. The company says CoSeal has the potential to significantly reduce surgery times and minimize complications.

"My initial experience with CoSeal has been excellent, and I believe this product represents a significant advancement in surgical sealing,” said Hazim J. Safi, M.D., chairman of cardiothoracic and vascular surgery, University of Texas-Houston Medical School, and a CoSeal clinical investigator.




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